Genomes are packaged as chromatin in nucleosomes composed of core histones (H2A/H2B/H3/H4).  Epigenetic processes, mediated by histone post-translational modifications, allow continued gene expression/repression in cell lineages.  Understanding how such ‘marks’ establish and propagate chromatin states is critical for specifying and maintaining distinct cell types.  Moreover, epigenetic states provide a source of phenotypic variation, independent of DNA sequence.

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